Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.
Identifieur interne : 000921 ( Main/Exploration ); précédent : 000920; suivant : 000922Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.
Auteurs : Reinhard Stauder [Autriche] ; Ge Yu [Royaume-Uni] ; Karin A. Koinig [Autriche] ; Tim Bagguley [Royaume-Uni] ; Pierre Fenaux [France] ; Argiris Symeonidis [Grèce] ; Guillermo Sanz [Espagne] ; Jaroslav Cermak [République tchèque] ; Moshe Mittelman [Israël] ; Eva Hellström-Lindberg [Suède] ; Saskia Langemeijer [Pays-Bas] ; Mette Skov Holm [Danemark] ; Krzysztof M Dry [Pologne] ; Luca Malcovati [Italie] ; Aurelia Tatic [Roumanie] ; Ulrich Germing [Allemagne] ; Aleksandar Savic [Serbie] ; Corine Van Marrewijk [Pays-Bas] ; Agnès Guerci-Bresler [France] ; Elisa Lu O [Espagne] ; Jackie Droste [Pays-Bas] ; Fabio Efficace [Italie] ; Alex Smith [Royaume-Uni] ; David Bowen [Royaume-Uni] ; Theo De Witte [Pays-Bas]Source :
- Leukemia [ 1476-5551 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Caractères sexuels (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Qualité de vie (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Syndromes myélodysplasiques (psychologie), État de santé (MeSH), Études prospectives (MeSH).
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.
DOI: 10.1038/s41375-018-0089-x
PubMed: 29572506
PubMed Central: PMC5990524
Affiliations:
- Allemagne, Autriche, Danemark, Espagne, France, Grèce, Israël, Italie, Pays-Bas, Pologne, Roumanie, Royaume-Uni, République tchèque, Serbie, Suède
- Bohême centrale, Communauté de Madrid, District de Düsseldorf, Grand Est, Gueldre, Latium, Lorraine (région), Rhénanie-du-Nord-Westphalie, Svealand, Île-de-France
- Düsseldorf, Madrid, Nancy, Nimègue, Paris, Prague, Rome, Stockholm
Links toward previous steps (curation, corpus...)
Le document en format XML
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Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medicine, Division of Hematology, University of Patras Medical School, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERONC, Instituto Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cermak, Jaroslav" sort="Cermak, Jaroslav" uniqKey="Cermak J" first="Jaroslav" last="Cermak">Jaroslav Cermak</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Mittelman, Moshe" sort="Mittelman, Moshe" uniqKey="Mittelman M" first="Moshe" last="Mittelman">Moshe Mittelman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Langemeijer, Saskia" sort="Langemeijer, Saskia" uniqKey="Langemeijer S" first="Saskia" last="Langemeijer">Saskia Langemeijer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Holm, Mette Skov" sort="Holm, Mette Skov" uniqKey="Holm M" first="Mette Skov" last="Holm">Mette Skov Holm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="M Dry, Krzysztof" sort="M Dry, Krzysztof" uniqKey="M Dry K" first="Krzysztof" last="M Dry">Krzysztof M Dry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa</wicri:regionArea><wicri:noRegion>Warszawa</wicri:noRegion></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tatic, Aurelia" sort="Tatic, Aurelia" uniqKey="Tatic A" first="Aurelia" last="Tatic">Aurelia Tatic</name><affiliation wicri:level="1"><nlm:affiliation>Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Germing, Ulrich" sort="Germing, Ulrich" uniqKey="Germing U" first="Ulrich" last="Germing">Ulrich Germing</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Savic, Aleksandar" sort="Savic, Aleksandar" uniqKey="Savic A" first="Aleksandar" last="Savic">Aleksandar Savic</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad</wicri:regionArea><wicri:noRegion>Novi Sad</wicri:noRegion></affiliation></author><author><name sortKey="Van Marrewijk, Corine" sort="Van Marrewijk, Corine" uniqKey="Van Marrewijk C" first="Corine" last="Van Marrewijk">Corine Van Marrewijk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Guerci Bresler, Agnes" sort="Guerci Bresler, Agnes" uniqKey="Guerci Bresler A" first="Agnès" last="Guerci-Bresler">Agnès Guerci-Bresler</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Lu O, Elisa" sort="Lu O, Elisa" uniqKey="Lu O E" first="Elisa" last="Lu O">Elisa Lu O</name><affiliation wicri:level="1"><nlm:affiliation>Servicio d'Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio d'Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Droste, Jackie" sort="Droste, Jackie" uniqKey="Droste J" first="Jackie" last="Droste">Jackie Droste</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Efficace, Fabio" sort="Efficace, Fabio" uniqKey="Efficace F" first="Fabio" last="Efficace">Fabio Efficace</name><affiliation wicri:level="3"><nlm:affiliation>Fondazione GIMEMA Onlus, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione GIMEMA Onlus, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York</wicri:regionArea><wicri:noRegion>New York</wicri:noRegion></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation wicri:level="1"><nlm:affiliation>St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="De Witte, Theo" sort="De Witte, Theo" uniqKey="De Witte T" first="Theo" last="De Witte">Theo De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29572506</idno><idno type="pmid">29572506</idno><idno type="doi">10.1038/s41375-018-0089-x</idno><idno type="pmc">PMC5990524</idno><idno type="wicri:Area/Main/Corpus">000887</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000887</idno><idno type="wicri:Area/Main/Curation">000887</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000887</idno><idno type="wicri:Area/Main/Exploration">000887</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.</title><author><name sortKey="Stauder, Reinhard" sort="Stauder, Reinhard" uniqKey="Stauder R" first="Reinhard" last="Stauder">Reinhard Stauder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria. reinhard.stauder@i-med.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Ge" sort="Yu, Ge" uniqKey="Yu G" first="Ge" last="Yu">Ge Yu</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York</wicri:regionArea><wicri:noRegion>New York</wicri:noRegion></affiliation></author><author><name sortKey="Koinig, Karin A" sort="Koinig, Karin A" uniqKey="Koinig K" first="Karin A" last="Koinig">Karin A. Koinig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Bagguley, Tim" sort="Bagguley, Tim" uniqKey="Bagguley T" first="Tim" last="Bagguley">Tim Bagguley</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York</wicri:regionArea><wicri:noRegion>New York</wicri:noRegion></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Symeonidis, Argiris" sort="Symeonidis, Argiris" uniqKey="Symeonidis A" first="Argiris" last="Symeonidis">Argiris Symeonidis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medicine, Division of Hematology, University of Patras Medical School, Patras</wicri:regionArea><wicri:noRegion>Patras</wicri:noRegion></affiliation></author><author><name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERONC, Instituto Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cermak, Jaroslav" sort="Cermak, Jaroslav" uniqKey="Cermak J" first="Jaroslav" last="Cermak">Jaroslav Cermak</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Mittelman, Moshe" sort="Mittelman, Moshe" uniqKey="Mittelman M" first="Moshe" last="Mittelman">Moshe Mittelman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Langemeijer, Saskia" sort="Langemeijer, Saskia" uniqKey="Langemeijer S" first="Saskia" last="Langemeijer">Saskia Langemeijer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Holm, Mette Skov" sort="Holm, Mette Skov" uniqKey="Holm M" first="Mette Skov" last="Holm">Mette Skov Holm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="M Dry, Krzysztof" sort="M Dry, Krzysztof" uniqKey="M Dry K" first="Krzysztof" last="M Dry">Krzysztof M Dry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa</wicri:regionArea><wicri:noRegion>Warszawa</wicri:noRegion></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tatic, Aurelia" sort="Tatic, Aurelia" uniqKey="Tatic A" first="Aurelia" last="Tatic">Aurelia Tatic</name><affiliation wicri:level="1"><nlm:affiliation>Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Germing, Ulrich" sort="Germing, Ulrich" uniqKey="Germing U" first="Ulrich" last="Germing">Ulrich Germing</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Savic, Aleksandar" sort="Savic, Aleksandar" uniqKey="Savic A" first="Aleksandar" last="Savic">Aleksandar Savic</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad</wicri:regionArea><wicri:noRegion>Novi Sad</wicri:noRegion></affiliation></author><author><name sortKey="Van Marrewijk, Corine" sort="Van Marrewijk, Corine" uniqKey="Van Marrewijk C" first="Corine" last="Van Marrewijk">Corine Van Marrewijk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Guerci Bresler, Agnes" sort="Guerci Bresler, Agnes" uniqKey="Guerci Bresler A" first="Agnès" last="Guerci-Bresler">Agnès Guerci-Bresler</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Lu O, Elisa" sort="Lu O, Elisa" uniqKey="Lu O E" first="Elisa" last="Lu O">Elisa Lu O</name><affiliation wicri:level="1"><nlm:affiliation>Servicio d'Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio d'Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Droste, Jackie" sort="Droste, Jackie" uniqKey="Droste J" first="Jackie" last="Droste">Jackie Droste</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Efficace, Fabio" sort="Efficace, Fabio" uniqKey="Efficace F" first="Fabio" last="Efficace">Fabio Efficace</name><affiliation wicri:level="3"><nlm:affiliation>Fondazione GIMEMA Onlus, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione GIMEMA Onlus, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York</wicri:regionArea><wicri:noRegion>New York</wicri:noRegion></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation wicri:level="1"><nlm:affiliation>St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="De Witte, Theo" sort="De Witte, Theo" uniqKey="De Witte T" first="Theo" last="De Witte">Theo De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="eISSN">1476-5551</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Female (MeSH)</term><term>Health Status (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Myelodysplastic Syndromes (psychology)</term><term>Prospective Studies (MeSH)</term><term>Quality of Life (MeSH)</term><term>Sex Characteristics (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Caractères sexuels (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Qualité de vie (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Syndromes myélodysplasiques (psychologie)</term><term>État de santé (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Syndromes myélodysplasiques</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Quality of Life</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Caractères sexuels</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Qualité de vie</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>État de santé</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29572506</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5551</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>6</Issue><PubDate><Year>2018</Year><Month>06</Month></PubDate></JournalIssue><Title>Leukemia</Title><ISOAbbreviation>Leukemia</ISOAbbreviation></Journal><ArticleTitle>Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.</ArticleTitle><Pagination><MedlinePgn>1380-1392</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41375-018-0089-x</ELocationID><Abstract><AbstractText>In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stauder</LastName><ForeName>Reinhard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria. reinhard.stauder@i-med.ac.at.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Ge</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0891-2501</Identifier><AffiliationInfo><Affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koinig</LastName><ForeName>Karin A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bagguley</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fenaux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service d'Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Symeonidis</LastName><ForeName>Argiris</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanz</LastName><ForeName>Guillermo</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2767-8191</Identifier><AffiliationInfo><Affiliation>Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cermak</LastName><ForeName>Jaroslav</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Hematology, Institute of Hematology & Blood Transfusion, Praha, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mittelman</LastName><ForeName>Moshe</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine A, Tel Aviv Sourasky (Ichilov) Medical Center and Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hellström-Lindberg</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langemeijer</LastName><ForeName>Saskia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holm</LastName><ForeName>Mette Skov</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mądry</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Hematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malcovati</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tatic</LastName><ForeName>Aurelia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Germing</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savic</LastName><ForeName>Aleksandar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Clinic of Hematology - Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Marrewijk</LastName><ForeName>Corine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerci-Bresler</LastName><ForeName>Agnès</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service d'Hématologie, Center Hospitalier Universitaire Brabois Vandoeuvre, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luño</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Servicio d'Hematología, Servicio de Salud del Principado de Asturias Oviedo, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Droste</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Efficace</LastName><ForeName>Fabio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Fondazione GIMEMA Onlus, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, New York, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowen</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Witte</LastName><ForeName>Theo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>I 1576</GrantID><Agency>Austrian Science Fund FWF</Agency><Country>Austria</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Leukemia</MedlineTA><NlmUniqueID>8704895</NlmUniqueID><ISSNLinking>0887-6924</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006304" MajorTopicYN="N">Health Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009190" MajorTopicYN="N">Myelodysplastic Syndromes</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012727" MajorTopicYN="N">Sex Characteristics</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>12</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>01</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29572506</ArticleId><ArticleId IdType="doi">10.1038/s41375-018-0089-x</ArticleId><ArticleId IdType="pii">10.1038/s41375-018-0089-x</ArticleId><ArticleId IdType="pmc">PMC5990524</ArticleId><ArticleId IdType="mid">EMS76032</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Br J Haematol. 2016 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